Elevated Prevalence of 35-44 FMR1 Trinucleotide Repeats in Women With Diminished Ovarian Reserve
نویسندگان
چکیده
منابع مشابه
Epigenetic Aberration of FMR1 Gene in Infertile Women with Diminished Ovarian Reserve
OBJECTIVES The diminished ovarian reserve (DOR) is a condition characterized by a reduction in the number and/or quality of oocytes. This primary infertility disorder is usually accompanied with an increase in the follicle-stimulating hormone (FSH) levels and regular menses. Although there are many factors contributing to the DOR situation, it is likely that many of idiopathic cases have geneti...
متن کاملP-203: Examination of FMR1 Gene Transcription and Protein Expression in Patients with Diminished Ovarian Reserve Reffered to Royan institute
Background: Diminished ovarian reserve (DOR) is a primary infertility disorder characterized by a reduction in the number and/or quality of oocytes, usually accompanied by high follicle-stimulating hormone (FSH) levels and regular menses. DOR aetiology factors are different, such as genetic factors, ageing, autoimmune disorders, adrenal gland impairment factors and iatrogenic causes, e.g. chemo...
متن کاملI-32: Management of Diminished Ovarian Reserve
The standard goal of all fertility treatments is the improvement of pregnancy rates in infertile patients. Within the last 20 years, ovulation induction has contributed to the success of assisted reproduction techniques e.g. in vitro fertilization (IVF) and embryo-transfer (ET). The efficacy of these techniques depends on a personalized protocol of controlled ovarian hyperstimulation (COH) and ...
متن کاملIn vitro fertilization outcome in women with diminished ovarian reserve
OBJECTIVE This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patie...
متن کاملP-204: Evaluation of FMR1 Gene Regulatory Region for The Epigenetic Mark of H3K9 Acetylation in Blood Cells of Patients with Diminished Ovarian Reserve Reffered to Royan Institute
Background: Diminished ovarian reserve (DOR) is a heterogeneous disorder causing infertility, characterized by a decreased number of oocytes and high FSH level, the genetic cause of which is still unknown. The association between FMR1 premutations(50-200 CGG repeats) and the premature ovarian failure( POF) disease has suggested that FMR1 gene acts as a risk factor for POF and recently for DOR p...
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ژورنال
عنوان ژورنال: Reproductive Sciences
سال: 2012
ISSN: 1933-7191,1933-7205
DOI: 10.1177/1933719112446074